TL;DR

DeSci and Web3BlockchainFusion：DeSci combinesBlockchainTechnologies designed to improve key aspects of scientific research, such as peer review, funding, intellectual property management, and data transparency.

How DeSci affects scientific research: DeSci has the potential to increase transparency, efficiency, and democratize scientific research while providing new opportunities to solve global problems.

Challenges and future prospects: Including improving peer review mechanisms, funding support challenges, protecting data privacy, and increasing diversity participation and promoting the integration of DeSci with traditional scientific fields.

what isDeSci?

DeSci’s development and Web3 technology, especiallyBlockchainIt represents a new approach to scientific research, which is centered on usingBlockchainDeSci is a company that uses technology to solve some fundamental problems in traditional scientific research. The development of DeSci focuses on improving peer review, funding, intellectual property management, and data transparency and review, which are key links in the traditional scientific research process.

The main features of DeSci are:

• Peer review and publication process：The traditional scientific publishing process is managed by journals, which usually involves lengthy peer review and editing. Blockchain technology, especially smartcontract, can be used to simplify this process. DecentralizationCommunityThe construction and introduction of a reputation system can improve the efficiency and transparency of the process.DAOIt is an organization that applies blockchain technology in peer review and reputation systems.

• Funding:Xiaobai NavigationTraditional scientific funding models often involve lengthy application processes and are susceptible to bias by review groups. Blockchain technology offers an alternative that allows scientific research to be funded directly through crowdfunding. For example, Molecule is a blockchain-based funding marketplace that connects patients, biotech companies or investors with scientists to promote the development of an open research market.

• Intellectual Property Management：In the field of DeSci, the introduction of intellectual property NFT (IP-NFT) enables researchers to share ownership of research projects and future results. Molecule is a pioneer in this regard. Through IP-NFT, scientists, biomedical researchers and biotechnology companies can more easily obtain funding and commercialize.

• Data transparency and auditing：The application of blockchain technology also increases data transparency, allowing scientific research data to be stored and accessed in a decentralized environment. This helps break down data silos and promote collaboration in projects and research.

The impact and prospects of DeSci

• Simplification of industrial transformation: Due to the ownership of intellectual property rights and complex processes of universities or research institutions, the industrial transformation process of academic achievements is usually long and complicated. DeSci provides new opportunities for the transformation of academic achievements into commercialization and simplifies this process. By building intellectual property NFTs and other innovative mechanisms, DeSci helps researchers transform their scientific research results into commercial products more directly. In addition, DeSci also helps VCs discover "under the table" projects, that is, research projects that are not yet widely known but have potential.

• Breaking traditional boundaries: DeSci is not limited to the field of scientific research. Its concepts and tools are also applicable to the arts, humanities, and even native knowledge systems. This interdisciplinary collaboration and knowledge sharing is one of the important features of DeSci.

• Inspiring new forms of collaboration: DeSci, through its decentralized nature, is able to foster collaboration on a global scale, especially for projects that require global environmental data and multidisciplinary input. In this way, DeSci has the potential to address some of the most pressing global issues, such as climate change and public health crises.

Key technologies and applications of DeSci

1. Blockchain and Smartcontract：区块链在DeSci中起到核心作用，尤其是智能合约。智能合约是自动执行的代码片段，可用于自动化科学出版流程的各个环节，例如同行评审。这些合约可确保流程的透明性和效率，同时也减少了传统出版的时间和成本。

2. Decentralized peer review and publishing process：DeSci uses blockchain technology to eliminate the middlemen in the traditional publishing process, such as journal coordination, thereby improving the accessibility and transparency of research results. For example, Ants Review directly intervenes in the interaction between authors and reviewers through smart contracts toTokenTo provide incentives and improve the efficiency and quality of peer review.

3. CommunityRaising research funds：区块链技术也用于众筹，使科学家能够直接与患者、生物技术公司或投资者连接，为开放研究市场提供动力。这种资金模式允许科学家绕过传统的资助渠道，直接从社区获得支持。例如，Molecule通过NFT和DAO等方式为药物开发等科学研究筹集资金。

4. Intellectual Property Management：In DeSci, NFTs are used to manage and develop intellectual property, such as scientific data or articles. This makes the sharing and transformation of intellectual property more efficient, while also providing a new source of income for scientists and researchers. For example, Molecule uses IP-NFTs to share ownership of research projects and their future results.

5. Data transparency and auditing：Data hosted on the blockchain increases the transparency of scientific research, allowing scientists to easily access and store databases of relevant research, allowing them to make more accurate research decisions. DeSci takes advantage of a unique feature of blockchain technology - the "permanent network". This means that once data is uploaded to the blockchain, it is almost impossible to delete or modify it. This feature is particularly important for scientific research because it ensures that scientific data and discoveries remain unchanged and accessible even in the face of political or social pressure. This is especially critical for protecting the integrity of scientific research and countering censorship, ensuring the freedom and objectivity of scientific research.

6. Decentralized research tools and publishing platform：DeSci provides multi-functional decentralized platforms such as DeSci Node and LabDAO to support the scientific research process, including seamless integration of reports, charts, codes and external APIs in various formats.

7. Establishing a reputation system：In order to build a high-quality and trustworthy DeSci community, the platform needs to establish a complete reputation system to track user interactions on the decentralized platform, such as likes, comments, and publications, to help build credibility and expertise. Through the blockchain, scientists' contributions - whether it is peer review, sharing of research data, or participation in professional training and guidance - can be recorded and authenticated by issuing NFTs. These NFTs not only serve as direct evidence of scientists' contributions, but also as a measure of their reputation in the scientific community. This system encourages scientists to participate in community building and knowledge sharing, while providing a more objective and transparent way to evaluate and reward their work.

8. The social platform for academics: ResearchGate in web2 has raised more than 100M in total.web3This platform provides a new way for scientists, researchers and other stakeholders to communicate and collaborate. Through such a social platform, scientists can share research results and seek partners, while also providing VCs with a channel to discover and invest in potential scientific research projects.

DeSci Ecological Project

Molecule

Molecule is a decentralized biotech research fundraising platform, with about 40 scientists currently looking for funding for their projects on the platform. Inspired by the citizen science movement and the idea of open drug development, Molecule's original idea came from the patient community and aims to help advance and fund early drug development. Molecule is built on Ethereum and includes two main systems: Molecule Discovery and Molecule Finance. These systems create an active ecosystem for decentralized modular drug development. Molecule uses a combination of smart contracts and legal contracts to form intellectual property NFTs (IP-NFTs), a new mechanism that allows anyone to share ownership of research projects and their future results, such as intellectual property, royalties, data, etc. Molecule is not limited to the basic functions of its own website, but has established a complete and large ecosystem that enables patient collectives and drug development DAOs to maintain, manage and interact with real-world intellectual property.

Data Lake

Data Lake 是一个利用区块链技术构建的创新医疗数据捐赠平台，旨在支持医学研究和人工智能的发展。它通过 Polygon 和自身的代币系统（$LAKE）建立了一个桥梁，连接愿意捐赠医疗数据的患者和需要这些数据的研究人员。这一平台的目标是促进疾病治疗方法和新疗法的发现，从而改善医疗保健服务和患者的治疗效果。

The Data Lake works by obtaining access to medical data from donors’ healthcare providers and then anonymizing that data to make it accessible to researchers.SafetyIn addition, the platform allows hospitals and data donors to share the economic returns generated by medical data, thereby encouraging more individuals and institutions to participate in the sharing of medical data. In this way, Data Lake protects personal privacy and promotes the advancement of medical research.

GenomesDAO

GenomesDAO is a biotech decentralized autonomous organization (DAO) focused on monetizing genomic data. It combines the concepts of decentralized finance (DeFi) to ensure the monetization of genomic data.SafetyThe following are the main features of GenomesDAO:

GenomesDAO 的目标是在保障个人隐私的同时，促进基因组学研究的发展和新药的创新。通过其平台，GenomesDAO 将个人基因数据转化为有价值的资源，同时确保数据的安全和隐私得到保护。

• Service Target：GenomesDAO 面向个人和组织，为个人提供全基因组测序服务、个性化的基因组报告以及安全的个人 DNA 保险库存储。对于组织，它提供技术支持，创建安全的、参与者拥有的基因组数据库。

• Research Support: Providing researchers with access to high-quality genomic datasets to help them understand the causes of disease and develop new drugs.

• 代币应用: Use GENE tokens to pay for whole genome sequencing services and as an incentive for querying using their encrypted DNA data vault.

HairDAO

HairDAO is a decentralized organization dedicated to treating hair loss, with an open source investment and operation model. It aims to promote the research and development of hair loss treatment in a democratized way and provide financial support for early stage hair loss research and related companies.

Here are some of the features of HairDAO:

• Diversified participation: HairDAO encourages people with all kinds of skills to join, whether they are technical skills or expertise in a specific field.

• Reward Mechanism: Through its token $HAIR, HairDAO rewards those who contribute to solving the problem of hair loss. Users can earn $H by uploading their anonymous, encrypted genome data.AIR as a reward.

• Cultural characteristics：Although it focuses on scientific research, HairDAO displays a relaxed and humorous style on its official website and Twitter, which is in sharp contrast to traditional scientific research projects. Its content expression and design style are eclectic, and even have a humorous temperament like a pantomime old movie.

• Meme Temperament: In the DeSci field, HairDAO stands out with its "hair loss" theme and light-hearted and humorous image. Its Twitter even uses the hair salon emoji symbol, enhancing its characteristics as a meme coin.

VitaDAO

VitaDAO is a decentralized drug development and community-managed biotech DAO initiated by Molecule, which is a leader in research and development in the field of longevity. As the world's first biotech DAO, VitaDAO's main goal is to promote the advancement of longevity research and extend human lifespan and healthspan.

The following are some of the core features of VitaDAO:

To incentivize the funding of early-stage longevity biomedical research, VitaDAO combines innovative governance frameworks and financial tools such as DAOs, NFTs, and AMMs. VitaDAO, which runs on Ethereum, not only co-funds research, but also digitizes research results into IP NFTs. The token VITA issued by VitaDAO can be obtained by contributing work, funds, or other resources such as data and IP to VitaDAO. Members who own VITA can not only participate in the democratic governance of VitaDAO and guide its research direction, but also profit from its data repository and manage its intellectual property portfolio. This model promotes innovation and democratization of scientific research, while providing community members with the opportunity to directly participate in scientific decision-making and benefit.

• Community Governance：VitaDAO is governed by community members holding $VITA tokens and focuses on funding early-stage longevity research projects.

• Funded Projects: Has funded more than 20 research projects totaling more than $6 million, covering research on age-related diseases and the exploration of new treatments.

• Research Scope：The supported research projects include basic research and preclinical research.

• Voting rights of token holders：$VITA token holders participate in the decision-making process of VitaDAO, including the selection of project funding, fund management and governance activities.

ResearchHub

ResearchHub was founded by Brian Armstrong, co-founder of Coinbase, and aims to change the traditional scientific journal publishing model. The platform recently completed a $5 million Series A financing on June 15. ResearchHub has created a "Hub" system that replaces traditional journals, allowing scientists or scholars to publicly publish and discuss scientific or academic content directly in these hubs, thereby bypassing the review process of traditional publishing, accelerating the dissemination of information, and conducting peer review after publication.

Users’ activities on ResearchHub can earn ResearchCoin (RSC) rewards, which is an ERC-20 token issued on the Ethereum platform for scientific research. cryptocurrencyRSC aims to incentivize the scientific community to share, review and curate information. Users can earn RSC rewards by:

In addition, users can set up RSC bounties for peer reviews, paper abstracts, or new methods in their labs. It is also possible to raise funds in forum posts before research work begins by “pre-registering” projects.cryptocurrencyAccording to ResearchHub, activity on the platform has grown over time, with peer review activity being the most active and promising.

• Share PDFs of research papers (provided they do not infringe copyright)

• Comment and discuss scientific research

• Peer review of scientific papers

• Receive RSC tips from other users

• Develop open source features

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Comparison between DeSci and traditional scientific research environment

The DeSci environment provides a more decentralized, transparent and collaborative scientific research environment, in stark contrast to the traditional, more centralized and closed-door scientific research environment.

Challenges and future prospects of DeSci

• Current technical and operational challenges facing the DeSci field

  • Peer review mechanism：In DeSci, peer review is still a key quality control step. For example, Ants-Review proposed a blockchain-based incentive protocol to solve the expensive, inefficient and centralized problems in traditional peer review. However, this system still faces some key problems, such as the determination of review qualifications, prevention of malicious behavior and cheating, etc.

  • Project Funding：Although blockchain provides a new "crowdfunding" model, funding support for large scientific research projects remains a challenge. Small projects can use the NFR (non-homogeneous title confirmation) model to solve funding problems, but large projects usually require national-level investment.

  • Privacy Protection: In DeSci, it is important to find a balance between promoting transparency and collaboration and ensuring data confidentiality.Zero knowledge proof(ZKP) technology plays a key role in this regard.

  • Diverse Participation: The composition of the DeSci community reflects the existing demographics of the crypto and scientific fields, where women and other minority groups are underrepresented. This is not limited to gender differences, but also involves diversity in ethnic, geographic, and economic backgrounds. This lack of diversity can lead to bias and limited research directions, limiting the range of problems DeSci can explore and solve. To improve inclusivity, the DeSci project needs to actively attract and encourage participation from a wider group of people. This may include providing educational resources, building partnerships, and ensuring that diverse voices are heard in the decision-making process.

• DeSci's long-term impact and potential development paths

  • Innovative ways of raising funds: Platforms such as Gitcoin provide funding for projects through new mechanisms such as secondary funding.

  • Intellectual Property Management：For example, the Molecule project has created a new way to manage intellectual property by building intellectual property NFT (IP-NFT).

  • The development of data market: Open data markets will inspire new forms of collaboration, innovative database structures such as DBDAO, allowing individuals to benefit from their data.

  • Importance of emergency funding: DeSci's ability to raise research funds is particularly important when responding to emergencies, such as public health crises such as the COVID-19 pandemic. Traditional government funds are often allocated according to the fiscal year budget, which is not flexible and fast enough in the face of emergencies. In contrast, DeSci uses its decentralized nature to quickly mobilize resources and concentrate funds on key research and response measures. This speed and efficiency are difficult to match with traditional funding methods. This rapid response funding method may become a key tool for responding to global health emergencies in the future.

• How to promote the integration of DeSci and traditional scientific fields

  • Transparent use and management of funds：With the help of DeFi experience, DeSci can achieve more efficient use of funds.

  • Optimization of resource sharing: Through smart contracts, scientific research equipment and other resources can be shared more conveniently, promoting efficient use of resources.

  • Promotion of global cooperation: Decentralized science with the help of blockchain technology can promote collaboration on a global scale, especially for projects that require global environmental data.

  • AIGC技术的应用: Artificial intelligence content generation (AIGC) can be used to improve the productivity of scientific research texts and help better present research results.

  • Promoting open science and interdisciplinary collaboration：DeSci supports and strengthens the concept of open science, that is, making scientific research and data open to everyone, increasing transparency and accessibility. This helps to improve the quality and impact of scientific research. The DeSci environment encourages collaboration between different disciplines and breaks down traditional barriers between disciplines through blockchain and smart contract technology. Interdisciplinary collaboration is particularly important for solving complex problems such as climate change and public health crises.

Conclusion and Recommendations

• For scientific research institutions and investors, DeSci provides a novel approach to scientific research funding and project management. For example, the case of VitaDAO shows that through the DeSci model, scientific research projects can obtain financial support from DAOs in professional fields and be managed through voting by DAO members. This model provides researchers with transparency into the funding allocation process and enables funders to directly participate in the decision-making process.

• DeSci's main goal at the moment is to solve the problems of funding, organization, and transparency in scientific research. DeSci uses the transparency and immutability of blockchain technology to provide a new model for raising and managing scientific research funds. This model may promote closer collaboration between different research institutions and private funders, helping to narrow the "valley of death" between basic research and clinical research. At the same time, it may also provide young scientists with more opportunities to support non-traditional research.

• DeSci has greatly improved the efficiency of academic publishing. By decentralizing the peer review and publishing process, it reduces the time and complexity of publishing, allowing scientific knowledge to be disseminated more quickly. DeSci alleviates the monopoly problem in the traditional academic publishing market by providing an open and transparent platform. This helps increase publishing diversity and provide more researchers with publishing opportunities, thereby promoting the diversification and democratization of scientific research.

The article comes from the Internet:DeSci track status and future prospects

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